HYPOLACT
Prescription medication – ergot‑derived dopamine‑receptor
Product Classification
Type: Prescription medication – ergot‑derived dopamine‑receptor agonistdalilaldwaa.com.
Therapeutic class: Prolactin inhibitor; anti‑Parkinson agentdalilaldwaa.com.
Target population: Adults diagnosed with hyperprolactinemia or prolactin‑secreting adenomas; occasionally used as an adjunct in advanced Parkinson’s diseasedalilaldwaa.com.
Active Ingredient and Formulation
Cabergoline (0.5 mg per tablet): A long‑acting dopamine D₂ receptor agonist derived from ergotdalilaldwaa.com. By stimulating D₂ receptors in pituitary lactotroph cells, cabergoline inhibits adenylyl cyclase, reduces cyclic AMP and intracellular calcium, and therefore suppresses prolactin secretiondalilaldwaa.com.
Excipients: Typically include citric acid, lactose, croscarmellose sodium and magnesium stearate (ingredient list may vary by manufacturer).
Mechanism of Action
Dopaminergic action: Cabergoline binds with high affinity to dopamine D₂ receptors in the anterior pituitary, acting as a potent agonist. This suppresses prolactin synthesis and release, correcting hyperprolactinemiadalilaldwaa.com.
Additional effect: Because of its dopaminergic activity in the central nervous system, cabergoline can be used (often alongside levodopa) to alleviate symptoms of Parkinsonian syndromedalilaldwaa.com.
Indications (Uses)
Hyperprolactinemia: Treatment of disorders characterized by excessive prolactin, whether idiopathic or due to prolactin‑secreting adenomas By lowering prolactin, it normalizes menstrual cycles, reduces galactorrhea and improves fertility.
Prolactin‑secreting pituitary tumors (prolactinomas): Decreases tumor size and prolactin levels.
Adjunct in Parkinsonian syndrome: Used either as monotherapy during early symptomatic management or as an adjunct to levodopa in advanced
Dosage and Administration
Initial dose: Typically 0.25 mg twice a week. Dosage may be titrated up (e.g., 0.5 mg per week) depending on prolactin levels and clinical responsemy.clevelandclinic.org. Healthcare providers decide the precise regimen.
Administration: Oral tablets taken with water. To minimize stomach upset, tablets can be taken with food
Therapy adjustments: Doctors gradually adjust doses and monitor serum prolactin. Abrupt discontinuation should be avoided; always follow physician guidance.
Packaging and Storage
Packaging: Official price lists show that Hypolact is supplied in a bottle containing 2 tablets (0.5 mg each)doctornewsweb.com.
Storage: Keep tablets at room temperature (20–25 °C), away from moisture and heat Store in the original bottle and out of reach of children.
Warnings and Precautions
Hypersensitivity: Contraindicated in individuals allergic to cabergoline or other ergot derivativesmy.clevelandclinic.org.
Cardiac and fibrotic disorders: Patients with heart valve disease, pulmonary or pericardial fibrosis or uncontrolled hypertension should avoid cabergoline or use it with extreme cautionmy.clevelandclinic.org.
Pregnancy & lactation: Should not be used during pregnancy or while breastfeeding unless specifically directed by a physicianmy.clevelandclinic.org.
Psychiatric and impulse‑control effects: Rarely, patients may experience heightened urges such as gambling, eating or shopping; such behaviors must be reported immediatelymy.clevelandclinic.org.
Safety monitoring: Regular cardiovascular examinations and prolactin measurements are recommended.
Drug Interactions
Avoid combination with: Certain blood‑pressure medications, dopamine‑antagonist antipsychotics (e.g., haloperidol), metoclopramide and other ergot alkaloidsmy.clevelandclinic.org. Always inform healthcare providers of all medicines and supplements you are taking.
Side Effects
Common: Nausea, dizziness, headache, constipation and fatiguemy.clevelandclinic.org.
Serious (seek medical help): Shortness of breath, chest pain, swelling of ankles or hands (possible heart failure or valve disease), decreased urination (potential kidney injury)my.clevelandclinic.org.
Patients may also notice low blood pressure on standing or unusual impulsive behaviorsmy.clevelandclinic.org.
Manufacturer and Branding
Producer: The product is manufactured by EGPI (Egyptian Group for Pharmaceutical Industries) and distributed by Al Ansar for Marketing; Paxal Pharma markets it in various regionsdw2.org.
Brand presence: Hypolact is widely available in Egypt and neighboring countries as a cost‑effective therapy for hyperprolactinemia.
Unique Points
Long‑acting formula: Requires only twice‑weekly dosing, increasing adherence.
Potent and selective: High affinity for D₂ receptors ensures effective prolactin suppressiondalilaldwaa.com.
Flexible use: Suitable for both endocrine and neurological indications (hyperprolactinemia and Parkinson’s disease).
Small package: 2‑tablet bottle convenient for titration and reduces medication wastedoctornewsweb.com.